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Specific Expertise from QSC

The QSC provides expertise in the following areas:

  1. Data requests
    • - Requesting data/numbers from TCC
    • - Access counts and availability of ORIEN Avatar molecular data from PRBB
  2. Biostatistics: Data science including basic statistical modeling, data cleaning, experimental design and power calculations
    • - Statistical experimental design in cell line, animal study, and human behavioral intervention or clinical trial
    • - Calculate adequate sample sizes
    • - Perform statistical power calculations
    • - Design and execute randomization approaches
    • - Establish clearly defined outcomes/endpoints and relevant variables
    • - Assist in identifying appropriate statistical approaches (e.g. survival analysis, regression model, and mixed effect model)
  3. Bioinformatics: Bioinformatics algorithms and computational biology focused on ‘omics technologies
    • - Genetic ancestry estimations (genome-wide or at a locus of interest)
    • - Admixture mapping
    • - Genetic association studies (subset of genes/genome wide)
    • - Next-gen DNA sequencing variant identification (germ-line and somatic)
    • - Variant annotation and classification
    • - RNA sequencing expression analysis
    • - RNA sequencing fusion detection
    • - Putative Neoantigen identification
    • - Microarray/public data analysis
    • - Gene annotation
    • - Proteomics analysis
  4. Informatics: Data processing, data integration and web-based systems development
    • - Software/database development
    • - HIPAA-compliant high-quality data collection
    • - Data integration
    • - Data sharing
    • - Data submission to public repositories
    • - Data access to public repositories (eg. dbGAP, TCGA)