Specific Expertise from QSC
The QSC provides expertise in the following areas:
- Data requests
- - Requesting data/numbers from TCC
- - Access counts and availability of ORIEN Avatar molecular data from PRBB
- Biostatistics: Data science including basic statistical modeling, data cleaning, experimental design and power calculations
- - Statistical experimental design in cell line, animal study, and human behavioral intervention or clinical trial
- - Calculate adequate sample sizes
- - Perform statistical power calculations
- - Design and execute randomization approaches
- - Establish clearly defined outcomes/endpoints and relevant variables
- - Assist in identifying appropriate statistical approaches (e.g. survival analysis, regression model, and mixed effect model)
- Bioinformatics: Bioinformatics algorithms and computational biology focused on ‘omics technologies
- - Genetic ancestry estimations (genome-wide or at a locus of interest)
- - Admixture mapping
- - Genetic association studies (subset of genes/genome wide)
- - Next-gen DNA sequencing variant identification (germ-line and somatic)
- - Variant annotation and classification
- - RNA sequencing expression analysis
- - RNA sequencing fusion detection
- - Putative Neoantigen identification
- - Microarray/public data analysis
- - Gene annotation
- - Proteomics analysis
- Informatics: Data processing, data integration and web-based systems development
- - Software/database development
- - HIPAA-compliant high-quality data collection
- - Data integration
- - Data sharing
- - Data submission to public repositories
- - Data access to public repositories (eg. dbGAP, TCGA)